Risk Factors For Alcoholic Liver Disease (ALD)

Globally alcohol use disorder is the most common substance use disorder. after smoking and hypertension, alcohol is the commonest preventable cause of death. Alcohol is the commonest cause of end stage liver disease with 50 % deaths in cirrhosis related directly or indirectly. Alcoholic liver disease is a spectrum ranging from fatty liver, alcoholic hepatitis and cirrhosis with its complications. Fatty liver disease is seen in 90 % of patients and is reversible if one stops drinking alcohol. Approximately one third of patients progress to hepatitis and 10 % progress to cirrhosis

 

Risk factors for Alcoholic Liver disease (ALD)

1.Amount and duration : 30 gm of alcohol in women and 50 gm of alcohol in men for more than 5 years leads to significant liver disease

2.Pattern of intake :daily consumption without meals doubles the risk of cirrhosis, daily drinking and binge drinking also associated with severe disease

3.Gender : women are more susceptible to ALD with even low dose of consumption of alcohol

4.Genetic factors : it is not clear why only 10% of patients drinking excessive alcohol develop cirrhosis

Prevention is better than cure: it has been proved without doubt that abstinence reduces the severity of disease at all stages